腹膜透析溶液中的培养导向抗生素:以稳定性和兼容性为重点的系统性审查
Chau Wei Ling1, Kamal Sud2,3,4, Rahul Patel5
1Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia. clin6270@uni.sydney.edu.au.
Journal of nephrology
|August 7, 2023
概括
本综述评估了围透析溶液中的抗生素稳定性,用于治疗围炎,这对于对抗多药耐药菌株至关重要. 对于一些抗生素,可获得稳定性数据,但为了最佳使用,需要更多的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 腹膜炎是腹膜透析的常见并发症.
- 耐多药细菌菌株在治疗腹膜炎方面构成了重大挑战.
- 不太常见的抗生素可以提供替代治疗选择.
研究的目的:
- 系统地审查各种腹膜透析溶液中不太常见的抗生素的稳定性.
- 为了确定具有证明稳定性的抗生素,用于培养导向治疗腹膜炎.
主要方法:
- 在多个数据库 (Medline,Scopus,Embase,Google Scholar) 进行了全面的文献搜索,截至2023年1月25日.
- 包括的研究是最近没有审查的体外抗生素稳定性评估.
- 化学,物理,抗微生物和微生物稳定性是主要结果.
主要成果:
- 包括28篇文章,确定了18种超出先前审查的抗微生物药物.
- 在9种具有腹腔内剂量建议的抗生素中,有7种具有适用的稳定性数据.
- 特定的抗生素,如塞福塔克西姆,塞夫特里亚克森,达普托米,奥洛克萨,泰科普拉宁,托布拉米和斯福米在某些溶液中显示稳定性.
结论:
- 没有证实所有推的腹腔内抗生素的物理化学稳定性.
- 需要进一步的研究来确定抗生素的稳定性,特别是在以icodextrin为基础的和pH中性的溶液中.
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