化疗相关的心脏功能障碍:心肌工作指数的有用性
Daniela Di Lisi1,2, Girolamo Manno3, Cristina Madaudo3
1Division of Cardiology, University Hospital "Paolo Giaccone", Palermo, Italy. danydilis@hotmail.it.
心肌工作指数 (MWI) 显示癌症治疗期间心脏毒性的早期变化,可能在全球纵向应变 (GLS) 之前检测出亚临床心脏损伤. 建议采用综合方法进行监测.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 建立左心室全球纵向应变 (GLS) 来检测抗癌药物的亚临床心脏损伤.
- 由于其依赖于血液动力学负载条件,GLS存在局限性.
研究的目的:
- 评估非侵入性心肌工作指数 (MWI) 对于早期心脏毒性诊断的有用性.
- 在接受心脏毒性化疗的患者中,比较MWI与GLS.
主要方法:
- 评估了61名接受 antracycline,taxane 和 trastuzumab 化疗的乳腺癌患者.
- 心声检测在基线,3个月和6个月测量了LVEF,GLS和MWI.
- 亚临床心脏功能障碍被定义为GLS相对下降≥12%.
主要成果:
- 在3个月或6个月后没有观察到显著的LVEF减少.
- 3个月和6个月后,GLS和MWI的显著减少 (p <0.05).
- 31%的患者在6个月内发展出亚临床心脏功能障碍;MWI比GLS更早改变.
结论:
- 在化疗期间,MWI表现出显著的变化,在GLS变化之前.
- 建议使用GLS和MWI的多参数方法来监测心脏毒性.
- 早期发现心脏毒性对于癌症治疗期间的患者管理至关重要.
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