通过心脏动力学图表早期和准确地检测辐射引起的心脏损伤
Yuanyuan Tao1, Qinghua Sun2,3, Yuchun Wei1
1Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, Shandong, China.
Journal of cardiovascular translational research
|August 7, 2023
概括
心力动力图 (CDG) 能够早期检测辐射引起的心脏损伤. 这种非侵入性心电图学方法在组织病理损伤之前显示出显著的变化,为临床使用提供了潜力.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 辐射瘤学 辐射瘤学
背景情况:
- 辐射诱导心脏损伤 (RIHD) 是一个重要的临床问题.
- 早期发现RIHD对于患者管理至关重要.
- 需要使用非侵入性的方法来评估心脏动态.
研究的目的:
- 探索心动力学图 (CDG) 检测RIHD的可行性.
- 评估CDG作为辐射诱导心脏损伤的早期诊断工具.
- 在大鼠模型中,将CDG变化与组织病理学发现相关联.
主要方法:
- 通过使用动态建模和确定性学习,从心电图 (ECG) 信号生成心脏动力学图 (CDG).
- 通过波段变换和分析计算的CDG指数.
- 在Wistar大鼠中,RIHD是由一次40 Gy辐射剂对心脏顶部诱导的.
主要成果:
- 放射治疗后CDG度指数显著下降.
- 辐射暴露后CDG形状从正常变为不规则.
- 放射治疗后观察到心肌巨浸透和纤维化增加.
- CDG变化与组织病理学变化有显著的相关性,并且在它们之前发生.
结论:
- CDG是检测RIHD的一个可行的方法.
- CDG变化比心脏损伤的组织病理学证据更早发生.
- 这项研究为CDG在RIHD早期检测中的临床应用提供了实验基础.
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