系统性炎症而不是氧化应激与中度慢性阻塞性肺部疾病的身体表现有关
Luis Peñailillo1, Claudia Miranda-Fuentes1, Sebastián Gutiérrez1
1Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile.
Advances in experimental medicine and biology
|August 7, 2023
概括
患有慢性阻塞性肺病 (COPD) 的患者由于炎症和氧化应激增加,运动能力和肌肉力量降低. 在COPD患者中,较高的炎症标志物与较差的身体表现相关.
科学领域:
- 肺部医学 肺部医学
- 运动生理学 运动生理学
- 生物化学 生物化学
背景情况:
- 慢性阻塞性肺病 (COPD) 的特点是肌肉功能障碍,氧化能力降低,运动耐受性降低和健康状况受损.
- 系统性炎症和氧化应激与COPD相关的肌肉损伤的病理生理学有关.
研究的目的:
- 为了比较中度COPD患者和健康对照者的身体表现,全身炎症和氧化应激标志物.
- 调查身体表现和COPD中的血炎症/氧化应激标志物之间的关联.
主要方法:
- 招募10名中度慢性肺炎患者和10名健康对照.
- 测量系统性炎症 (瘤坏死因子-α [TNF-α]) 和氧化应激 (氨酸过氧化酶 [GPx] 活性,马隆迪化物 [MDA]) 血标志物.
- 评估最大有氧容量 (VO2峰值) 和最大同位测膝盖伸缩器强度 (MVIC).
主要成果:
- 与对照组相比,COPD患者的VO2峰值 (31.3%) 和MVIC (43.9%) 显著降低.
- 慢性肺炎患者的TNF-α显著增加 (79.6%) 和GPx活性降低 (27.5%).
- 在COPD患者中,TNF-α度与降低的MVIC (R=-0.48) 和VO2峰值 (R=-0.58) 中度相关.
结论:
- 与健康人相比,中度COPD患者表现出肌肉力量和有氧能力受损.
- 慢性肺炎患者表现出系统性炎症升高和抗氧化能力降低.
- 系统性炎症在慢性慢性病中适度与身体性能缺陷有关.
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