在医学中创建和采用大型语言模型
Nigam H Shah1,2,3, David Entwistle1, Michael A Pfeffer1,2
1Stanford Health Care, Palo Alto, California.
JAMA
|August 7, 2023
概括
大型语言模型 (LLM) 提供医疗效益,但积极参与至关重要. 我们必须通过医学数据和现实世界的测试来指导LLM的发展, 以确保安全有效地融入医疗保健.
科学领域:
- 医疗信息学
- 医疗保健中的人工智能
- 临床决策支持
背景情况:
- 对大语言模型 (LLM) 对潜在医疗应用的兴趣日益增长.
- 目前在医学领域的LLM课程往往缺乏具体的医学培训数据和效益验证.
- 如果不积极参与LLM整合,可能会失去主动性.
研究的目的:
- 强调需要积极参与塑造LLM在医学中的应用.
- 强调负责开发和部署LLM医疗工具的重要性.
- 倡导将人工智能整合到医疗保健中的积极做法.
主要方法:
- 分析目前在医疗任务中使用LLM的趋势.
- 识别医疗保健LLM培训和验证方面的差距.
- 为积极塑造LLM开发和部署提出框架建议.
主要成果:
- 在没有足够的医疗数据培训或福利验证的情况下,LLM应用程序越来越多地用于医疗任务.
- 消极观察可能会让人无法控制LLM如何重塑医疗实践.
- 积极塑造需要提供相关数据,定义好处,并对现实世界进行评估.
结论:
- 积极参与对于负责任地利用LLM在医学中的好处至关重要.
- 提供医疗数据,说明好处,实践测试对于安全的LLM整合至关重要.
- 积极的塑造确保了LLM的作用是增强而不是破坏医疗实践.
更多相关视频
05:47Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
287
05:56Objectification of Tongue Diagnosis in Traditional Medicine, Data Analysis, and Study Application
Published on: April 14, 2023
2.5K
相关概念视频
02:07Improving Translational Accuracy
11.6K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.6K
01:22Language Development
395
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
395
01:11Genetic Lingo
103.2K
Overview
103.2K
01:27Language and Cognition
375
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
375
02:28Leaky Scanning
5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
01:19MALDI-TOF Mass Spectrometry
4.9K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.9K