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阻塞的自与多层双氧化物诱导的反极化和瘤相关巨细胞中的免疫激活有关

Guoxin Jing¹, Linnan Yang², Hong Wang¹

¹Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200092, P. R. China.

Advanced healthcare materials

|August 7, 2023

概括

层状双氧化物 (LDHs) 可以重编程与瘤相关的巨细胞 (TAMs) 来对抗癌症. Mg-Al LDH通过抑制TAM自,增强抗瘤免疫力,显示出卓越的疗效.

科学领域:

免疫学免疫学免疫学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键免疫细胞.
TAMs表现出可塑性,在抗炎 (M2) 和促炎 (M1) 现型之间转移,影响瘤进展.
层状双氧化物 (LDHs) 已经显示出调节TAM偏振的潜力,但它们的机制尚不清楚.

研究的目的:

调查LDH中不同阴离子组合对TAM偏振的不同影响.
阐明LDHs调节TAM极性和抗瘤免疫力的基本机制.
在瘤模型中评估Mg-Al LDH的治疗潜力.

主要方法:

合成和Mg-Fe LDH和Mg-Al LDH的表征.
在体外评估TAM两极化 (M2到M1) 和骨髓衍生抑制细胞 (MDSC) 抑制.
在体内瘤生长抑制研究和免疫细胞透分析.
调查自在LDHs调节的TAM极化中的作用.

主要成果:

Mg-Al LDH显示出比Mg-Fe LDH更强大的能力,可以将M2 TAM重聚到M1并抑制MDSC的形成.
在体内,Mg-Al LDH显著抑制了瘤生长,并增强了免疫细胞透到TME.
Mg-Al LDH抑制了TAM自,这与TAM促炎活性有负相关性.

结论:

LDHs,特别是Mg-Al LDHs,可以通过抑制自而有效地将TAM重编程为抗瘤M1表型.
LDHs的离子组成对于它们的免疫调节功能至关重要.
基于LDH的材料有望作为癌症免疫疗法的免疫辅助剂.

关键词:

自自是自的过程.有层的双氧化.再极化再极化是什么意思与瘤相关的巨细胞.瘤免疫疗法免疫疗法

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