工程层次的微设备使预先编程的控制释放能够用于术后和不可切除的癌症治疗
Lihuang Wu1, Junhua Li1, Yuqi Wang1
1Research Institute for Biomaterials, Tech Institute for Advanced Materials Bioinspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Advanced materials (Deerfield Beach, Fla.)
|August 7, 2023
概括
新的微设备精确地控制癌症治疗的药物释放,改善胰腺癌和乳腺癌的治疗结果. 这项技术为手术后和不可切除的情况下管理瘤提供了一个有希望的替代方案.
科学领域:
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
- 在瘤学瘤学.
背景情况:
- 传统的全身癌症药物管理往往产生不令人满意的临床效益.
- 现有的药物输送系统难以为各种临床需求提供可编程的药物释放配置文件.
- 有效的癌症治疗需要改善对切除和不可切除瘤的药物输送.
研究的目的:
- 介绍一个微制造概念,分层多重聚合物固定 (HMPI).
- 设计基于可生物降解聚合物的层次式微型设备 (HMDs),用于预编程的控制药物释放.
- 评估HMD在胰腺癌和乳腺癌临床前模型中的疗效.
主要方法:
- 开发了HMPI策略,以创建可定制的等级微结构.
- 工程生物降解型HMD用于控制释放凝胺 (胰腺癌) 和多克索鲁比辛/帕克利塔塞尔组合 (乳腺癌).
- 用于术后胰腺癌,术后乳腺癌和不可切割的乳腺癌的临床前模型.
主要成果:
- 在临床前模型中,HMDs的治疗被证明是可以耐受和有效的.
- 成功抑制瘤生长,复发和转移.
- 根据临床计划,实现了多个疗程的受控,现场药物释放.
结论:
- 该HMPI战略使得能够创建具有精确控制药物释放概况的微设备.
- 工程化HMD显示出作为术后和不可切除瘤的替代治疗方法的巨大潜力.
- 这种方法为癌症治疗提供了可定制的解决方案,有可能改善患者的治疗结果.
相关概念视频
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