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影响瘤透淋巴细胞和PD-L1表达模式的基因组变化在三阴性乳腺癌中

Han Wang¹, Xiao-Hong Ding^1,2, Cheng-Lin Liu¹

¹Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Journal of the National Cancer Institute

|August 7, 2023

概括

基因组变化可以悖论地影响瘤透淋巴细胞 (TIL) 和PD-L1表达在三阴性乳腺癌,影响患者的预后和免疫治疗反应. 了解这些因素是精密治疗的关键.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
基因组学就是基因组学.

背景情况:

瘤透淋巴细胞 (TIL) 和PD-L1表达是三阴性乳腺癌 (TNBC) 结果的不完美预测者.
影响这些生物标志物的基因组和转录组变化尚未完全理解.

研究的目的:

分析与TILs相关的基因组和转录组变化,PD-L1表达和TNBC中的患者结果.
调查TILs,PD-L1和预后之间的矛盾关系.

主要方法:

在TNBC多组数据集和免疫疗法队列中评估了PD-L1免疫组织化学得分 (SP142和28-8测定) 和TILs.
分析了与TILs,PD-L1和结果相关的基因组和转录组变化.

主要成果:

确定了与意想不到的TILs/PD-L1表达和TNBC的预后相关的基因组变化.
根据PD-L1和TIL水平将TNBC分为四组,揭示了不同的预后影响.
在TIL阴性/PD-L1阳性瘤中发现与PD-L1相关的拷贝数变化和瘤信号;在TIL阴性/PD-L1阴性瘤中涉及GSK3B降解.

结论:

基因组和转录组的改变可以在TILs,PD-L1表达和TNBC的预后之间产生矛盾的效应.
针对这些已识别的因素可以改善TNBC患者的精确免疫疗法.

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