疾病清除作为性结肠炎的新结果:系统性审查和专家共识
Ferdinando D'Amico1,2, Fernando Magro3, Britta Siegmund4
1Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Inflammatory bowel diseases
|August 7, 2023
概括
疾病清除,性结肠炎 (UC) 缓解的综合测量,被探索为治疗目标. 本系统性审查和德尔菲共识提出了标准化定义,并为其临床使用和试验提出了建议.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床试验方法论 临床试验方法论
背景情况:
- 性结肠炎 (UC) 管理的目标是缓解,但实现完整的疾病清除是一个复杂的目标.
- 疾病清除,定义为同时临床,内镜和组织学缓解,是UC的新兴治疗目标.
- 为了在临床实践和研究中有效实施疾病清除,需要标准化.
研究的目的:
- 系统地审查疾病清除在性结肠炎 (UC) 管理中的作用.
- 开发和提出一种标准化的疾病清除定义.
- 为实施疾病清除作为治疗目标提供实际建议.
主要方法:
- 系统性文献审查关于UC疾病清除的文献.
- 德尔菲方法涉及国际组织研究炎症肠病 (IOIBD) 成员.
- 关于疾病清除的陈述的制定和投票.
主要成果:
- 建立了疾病清除 (临床,内镜,组织学缓解) 的综合定义.
- 关于疾病清除的应用的声明是通过专家共识制定的.
- 在UC临床实践和试验中制定了标准化疾病清除的建议.
结论:
- 疾病清除在性结肠炎 (UC) 中是一个重要的治疗标.
- 标准化定义和实际建议对于一致的应用至关重要.
- 这种共识旨在通过定义和实施疾病清除来推进UC管理和研究.
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