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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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反调节HECT E3酶的泛化和相分离的反调节

Jingyu Li1, Kang Zhu1, Aihong Gu1

  • 1Department of Neurosurgery, Huashan Hospital, the Shanghai Key Laboratory of Medical Epigenetics, State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science, National Center for Neurological Disorders, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 7, 2023
PubMed
概括

斯巴丁蛋白激活E3结合酶,促进液体-液体相分离 (LLPS) 并通过自加速脂质滴滴的循环. 这一发现揭示了一个积极的反循环,增强了E3酶活性.

关键词:
在HECT类型的连接酶中.反法规反法规的规定.液体液体相分离器 液体相分离器脂质滴滴的周转.无处不在的化

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