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Updated: Jul 19, 2025

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使用小分子抑制剂向STING寡合化

Fiachra Humphries1, Liraz Shmuel-Galia1, Zhaozhao Jiang1

  • 1Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.

Proceedings of the National Academy of Sciences of the United States of America
|August 7, 2023
PubMed
概括

研究人员发现BB-Cl-amidine是一种小分子抑制剂,可以阻止干扰素基因刺激器 (STING) 信号传递. 这种化合物有效地减少了由细胞核DNA驱动的炎症反应,为STING相关的炎症性疾病提供了潜在的治疗方法.

关键词:
在Trex-1中使用.细胞因子 细胞因子蛋白质阿尔金宁减小酶的作用.小分子抑制剂小分子抑制剂干扰素基因的刺激剂.

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