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在自闭症下面的前额回环和精神化网络之间的连接性差异,与发展协调障碍和非自闭症青年相比

Aditya Jayashankar¹, Brittany Bynum², Christiana Butera¹

¹Center for Neuroscience of Embodied Cognition (CeNEC), Brain and Creativity Institute, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA; USC Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.

Cortex; a journal devoted to the study of the nervous system and behavior

|August 7, 2023

概括

自闭症谱系障碍 (ASD) 中在精神化任务期间的神经连接差异是ASD的特征,而不是运动障碍. 与对照人群相比,自闭症患者的下额 (IFG) 显示出独特的连接模式.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
认知神经科学认知神经科学

背景情况:

之前的研究发现,自闭症谱系障碍 (ASD) 个体在精神化任务期间,下额 (IFG) 的神经连接性降低.
由于IFG在运动处理中的作用以及ASD中运动困难的高患病率,需要调查观察到的连接差异是否与ASD特异或与运动障碍相关.
发育协调障碍 (DCD) 与ASD共享运动挑战,提供了一个相关的比较组.

研究的目的:

为了确定IFG在思维化任务中的功能连接差异是否特异于自闭症谱系障碍 (ASD) 或在发育协调障碍 (DCD) 中也存在.
为了比较神经连接模式在一个精神化任务跨个体与ASD,DCD,通常发展 (TD) 控制.

主要方法:

功能性磁共振成像 (fMRI) 用于扫描参与者 (29个ASD,20个DCD,31个TD;年龄在8-17岁) 进行精神化任务.
参与者被指示考虑观察到的行为背后的原因.
使用下额 (IFG) 作为种子区域来分析功能连接性.

主要成果:

与TD和DCD组相比,ASD组在精神化任务期间表现出显著的功能连接差异.
使用左IFG进行基于种子的分析,揭示了ASD与 temporoparietal junction (TPJ),insular cortex和dorsolateral prefrontal cortex (DLPFC) 的明显连接模式.
正确的IFG种子还显示了ASD与insula和DLPFC的连接性差异.

结论:

观察到的IFG与关键的思维,情感和运动处理区域之间的功能连接差异是自闭症谱系障碍 (ASD) 的特征.
这些发现表明,在精神化过程中ASD中独特的神经连接模式不能归因于经常在这种疾病中出现的同时发生的运动差异.

关键词:

自闭症自闭症自闭症发育协调障碍是一种发展协调障碍.精神化的精神化镜像神经元是一种神经元.神经发育条件神经发育条件思想的理论思想的理论.

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