下一代3D打印的阴道环用于预防艾滋病毒和意外怀孕
Isabella C Young1, Priya Srinivasan2, Roopali Shrivastava3
1Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Biomaterials
|August 7, 2023
概括
这项研究引入了第一个3D打印的多用途预防技术 (MPT) 阴道内环 (IVR) 用于HIV预防和避孕. 这种创新的IVR为需要有效,长效的预防方法的妇女和女孩提供了潜在的新选择.
科学领域:
- 生物医学工程 生物医学工程
- 生殖健康 生殖健康
- 3D打印技术的使用
背景情况:
- 全球有2千万名青少年女孩和年轻女性携带艾滋病毒,获得预防方法的机会有限.
- 全球有一半的怀孕仍然是意想不到的,尽管有可用的避孕方法.
研究的目的:
- 开发和评估第一个3D打印的多用途预防技术 (MPT) 阴道内环 (IVR).
- 评估设计用于HIV预防和避孕的IVR的安全性和有效性.
主要方法:
- 利用连续液体接口生产 (CLIPTM) 来制造MPT IVR,使用生物相容的基于的树脂.
- 将乙凝 (ENG),乙雌二醇 (EE) 和伊斯拉特拉维尔 (ISL) 装入IVR,只需一个步骤.
- 在体外和体内 (绵羊和) 评估药物释放,以及安全性评估.
主要成果:
- 在实验室中,ENG/EE/ISL IVR显示药物持续释放150天,在羊群中持续14天.
- 在绵羊中,没有观察到对宫和阴道健康,阴道活检或微生物组资料的不良影响.
- 在中,伊斯拉特拉维尔 (ISL) IVR在治疗药物水平下显示持续释放28天,并且耐受性良好,不会影响免疫标志物.
结论:
- 3D打印的MPT IVR显示为同时预防艾滋病毒和避孕的安全有效方法.
- 这项技术有可能显著扩大青少年女孩和年轻女性的预防选择.
- 进一步的研究和开发可能会为弱势群体带来一种新的,用户控制的预防方案.
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