相关实验视频
Updated: Jul 19, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
circWHSC1:人类癌症拼图中的一个圆形RNA片段
Sheyda Khalilian1, Zahra Mohajer2, Seyedeh Zahra Hosseini Imani3
1Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
像circWHSC1这样的循环RNAs (circRNAs) 通过海绵miRNAs和调节信号通路来促进癌症生长和转移. circWHSC1的上调与患者的生存率低下有关,将其标记为预后性癌症标志物.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
- 在瘤学瘤学.
背景情况:
- 循环RNAs (circRNAs) 是由非正规拼接形成的非编码RNA.
- 由WHSC1基因衍生出的circWHSC1在各种癌症中过度表达.
- circWHSC1 功能像一个miRNA海绵,调节关键信号通路.
研究的目的:
- 审查circWHSC1在不同癌症中的瘤效应.
- 巩固来自体外,体内和人体研究的证据.
- 为了突出circWHSC1作为预后标记物的潜力.
主要方法:
- 关于研究circ的研究的文献综述WHSC1.1.
- 在体外,体内和人体临床数据的分析.
- 关于circWHSC1分子机制和临床相关性的证据综合.
主要成果:
- circWHSC1过度表达与细胞生长,迁移,入侵和转移的增加有关.
- circWHSC1 作为多个miRNA的海绵 (例如,miR-195-5p,miR-145).
- circWHSC1影响像FASN/AMPK/mTOR和AKT3这样的途径,影响癌症的进展.
结论:
- circWHSC1在各种癌症中表现出显著的致癌潜力.
- 它在促进瘤进展中的作用及其与减少存活率的关联强调了其临床重要性.
- circWHSC1代表了癌症患者有前途的新型预后生物标志物.
相关概念视频
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Hedgehog Signaling Pathway
Abnormal Proliferation
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

