非常早产对青少年EEG连接,网络组织和长期结果的影响
C van 't Westende1, E S Twilhaar2, C J Stam3
1Amsterdam UMC, Department of Child Neurology, Amsterdam, the Netherlands.
概括
非常早产的青少年在贝塔频段显示大脑连接和网络组织的改变. 这些EEG差异与神经发育结果有关,但不能完全解释早产的影响.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 过早分娩与长期的神经发育挑战有关.
- 了解这些结果的神经支对于早期干预至关重要.
研究的目的:
- 为了比较功能连接和大脑网络组织在非常早产的青少年与定期出生的对照.
- 确定观察到的差异是否调解了早产和长期结果之间的关系.
主要方法:
- 高密度脑电图 (EEG) 用于47名非常早产和54名早产青少年 (13岁).
- 阶段滞后指数 (PLI) 和振幅外相关性 (AEC-c) 评估了五个频段的连接性.
- 使用最小跨树方法分析了大脑网络组织.
主要成果:
- 非常早产的青少年表现出更强的β频段PLI连接和更少的网络组织差异化.
- 贝塔频段AEC-c和网络差异化与长期结果 (智商,运动,注意力,学术) 有负相关性.
- EEG措施并没有显著调解早产和不良结果之间的联系.
结论:
- 非常早产的青少年表现出功能连接和大脑网络组织的改变,特别是在β频段.
- 这些神经生理学变化与神经发育功能有关.
- 脑电图连接和网络分析为研究功能障碍机制提供了一个有希望的方法.
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