结构特异性代谢由Bacillus subtilis var. 通过黄醇分子的结构特异性代谢. 纳托 BCRC 8051717 的使用情况
Che-Wei Wang1, Hsin-Ya Tsai1, Chen Hsu1
1Department of Agricultural Chemistry, National Taiwan University, Taipei 106, Taiwan.
Food chemistry
|August 7, 2023
概括
细菌细菌生物转化像奎尔丁和kaempferol在C环裂解产品的flavonols. 它还产生素酸衍生物,揭示了结构特定的新陈代谢途径,用于营养药开发.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 自然产品化学 自然产品化学
背景情况:
- 黄醇对人类健康具有有益的生物活性.
- 来自 Bacillus subtilis 的黄酸盐合成酶 (BsFPS) 增强了黄酸盐的水溶性和口服生物利用性.
- 不同类黄醇的体内代谢在很大程度上仍未确定.
研究的目的:
- 通过 Bacillus subtilis BCRC 80517.7 调查三种黄醇 (奎尔塞,凯姆菲罗尔和菲塞) 的生物转化.
- 为了阐明B. subtilis.中黄醇的结构特异性代谢途径.
- 探索用于营养药物应用的黄醇衍生物生物生产的潜力.
主要方法:
- 培养B. subtilis BCRC 80517使用奎尔塞丁,凯姆菲罗尔和菲塞丁.
- 使用分析技术对生物转化产品的分析 (摘要中未指明的细节).
- 基于产生的化合物,识别代谢途径.
主要成果:
- B. subtilis从氨酸和珀醇中制造出C环裂变产品,即2-protocatechuoyl-phloroglucinol碳酸酸 (2-PCPGCA),由氨酸和珀醇.
- 产生了两个菲塞酸衍生物,菲塞4'-O-酸和菲塞3'-O-酸.
- 代谢是结构特定的,而5基组影响了代谢优先级.
结论:
- B. subtilis对不同的黄醇具有不同的代谢途径.
- 5基团在决定黄醇的代谢命运方面起着至关重要的作用.
- 这些发现支持生物生产平台的发展,用于在营养保健品中使用的黄酸衍生物.
关键词:
2-protocatechuoyl-phloroglucinol 炭酸 (PubChem CID: 54675870) 的使用情况这种细菌是 Bacillus subtilis.生物转化 生物转化在C环上有裂痕.黄醇 (Flavonol) 是一种可以酸化是指酸化的方法.菲塞丁 (PubChem CID: 5281614) 的使用情况凯姆菲罗尔 (PubChem CID: 5280863) 是一种基酸 (PubChem CID: 3840) 是一种奎尔塞丁 (PubChem CID: 5280343) 是一种可以更多相关视频
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