相关实验视频

Updated: Jul 19, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

缺少BRCA的转移性前列腺癌具有不良的预后和独特的基因组表型

Heidi Fettke¹, Chao Dai², Edmond M Kwan³

¹Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

|August 7, 2023

概括

基因组对DNA损伤反应 (DDR) 基因的改变,特别是BRCA2,在转移性割抵抗性前列腺癌 (mCRPC) 中很常见. 这些变化表明生存率和治疗反应较差,突出显示了它们的预后价值.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
基因组学就是基因组学.

背景情况:

转移性割抵抗性前列腺癌 (mCRPC) 经常在DNA损伤反应 (DDR) 基因中表现出基因组变化.
了解这些改变对预后和治疗反应的影响对于改善患者的治疗结果至关重要.

研究的目的:

用血cfDNA研究mCRPC中DDR基因变异的流行率和临床意义.
在mCRPC患者中评估BRCA2变异的预后价值,包括结合性.

主要方法:

在375名mCRPC患者的407个血样本中对152个基因进行了向测序,其中包括27个DDR基因.
通过使用CLIA认证的无细胞DNA (cfDNA) 试验,评估BRCA2中的致病性变化和双性损失.

主要成果:

在34.5%的患者中发现了DDR变化,其中BRCA2 (19%),ATM (13%) 和FANCA (5%) 是最常见的.
BRCA变异,特别是BRCA2,与明显更差的无进展生存 (PFS) 和整体生存 (OS) 相关.
患有BRCA变异的患者对雄激素受体 (AR) 途径抑制剂的PSA反应率较差;BRCA2变异的致血性没有影响PFS.

结论:

在mCRPC中,BRCA基因,特别是BRCA2作为关键的预后生物标志物,表明结果不佳.
在cfDNA测定中BRCA2的预后效用可能独立于zygosity.
来自BRCA缺陷mCRPC的cfDNA的基因组变化表明未来临床试验中合理的共同向策略的潜力.

关键词:

这就是BRCA BRCA.生物标志物生物标志物没有细胞的DNA.前列腺前列腺前列腺前列腺癌是什么意思前列腺癌是什么意思 ctDNActDNA是什么意思

更多相关视频

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts

Published on: December 20, 2024

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

相关概念视频

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...