血红素和高心跳率对宾夕法尼亚州立大学12cc儿科心室辅助装置的影响
Sailahari V Ponnaluri1, Brady L Houtz1, Emma C Raich1
1From the Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
|August 7, 2023
概括
儿科心室辅助器件 (PVADs) 在不同血值和心率之间显示一致的流场. 调整操作条件可以优化PVAD的性能,并降低儿童凝块的风险.
科学领域:
- 生物医学工程 生物医学工程
- 儿童心脏病学 儿童心脏病学
- 流体动力学 流体动力学
背景情况:
- 先天性心脏病 (CHD) 每年影响约40,000名美国婴儿,其中25%需要干预.
- 儿科心室辅助器件 (PVAD) 作为一个关键的桥梁,以移植儿童由于捐赠者心脏稀缺.
- 现有的PVAD被优化为名义条件,但儿科患者表现出独特的生理变异,如波动的血红素和心率.
研究的目的:
- 为了评估12cc气动宾夕法尼亚州立大学PVAD在儿科特定的生理条件下的性能.
- 调查不同血红素和心率对PVAD内流动动力学和表面洗的影响.
- 确定操作调整是否可以减轻儿科患者血小板粘附和血栓形成的风险.
主要方法:
- 使用粒子图像速度计 (PIV) 来分析PVAD内的流体流.
- 采用了三种非牛顿血相应物,其血红素水平分别为20%,40%和60%.
- 测试了设备在两个不同的节拍:75bpm和120bpm,模拟儿科心率变化.
主要成果:
- 在所有测试的血红素水平和心跳率中观察到一致的流场模式,包括输入喷气和透气期间的固体旋转.
- 较高的速度大小在每分钟120拍,而不是每分钟75拍.
- 流场时间和表面洗效率的微小变化与不同的血红素水平有关.
结论:
- 宾夕法尼亚州立大学的PVAD显示出强大的流动特征,无论儿科血红素值或心率变化.
- 通过优化PVAD操作条件,可以实现有效的表面洗,这对于减少血小板粘附至关重要.
- 这些发现支持了量身定制PVAD操作的潜力,以提高儿科CHD患者的安全性和疗效.
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