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Updated: Jul 19, 2025

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脂质过氧化衍生的修饰及其对谷氨过氧化酶1活性的影响

Seon Hwa Lee1, Kazuyuki Takahashi1, Yusuke Hatakawa1

  • 1Department of Bio-analytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.

Free radical biology & medicine
|August 7, 2023
PubMed
概括

像4-oxo-2(E) -nonenal这样的脂质过氧化副产品不可逆地抑制了抗氧化酶氨酸过氧化酶1 (GPx1) 的抗氧化作用. 这种无活化通过增加细胞过氧化物来放大氧化应激,从而导致癌症和神经退行等疾病.

关键词:
4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔4-Oxo-2 (((E) -非尼纳尔葡萄氨酸过氧化酶1 葡萄氨酸过氧化酶1脂质过氧化过氧化质谱测量质量谱测量氧化应激是一种氧化应激.

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