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甲酸盐暴露与肥胖风险之间的关联:观察性研究的元分析

Qian Wu¹, Gang Li², Chen-Yang Zhao³

¹Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province 150086, China; Yichang Center for Disease Control and Prevention, Yichang, Hubei Province 443000, China.

Environmental toxicology and pharmacology

|August 7, 2023

概括

甲酸盐暴露与儿童和成人肥胖风险增加有关. 这一系统性审查证实了大量的关联,特别是在妇女和西方人群中,突出了对这些常见化学品的担忧.

科学领域:

环境健康环境健康
流行病学流行病学
毒理学毒理学毒理学

背景情况:

流行病学研究表明,甲酸盐暴露与肥胖之间存在联系,但研究结果经常受到争议.
酸盐是塑料和个人护理产品中常见的环境化学物质.
了解甲酸盐暴露和肥胖之间的关系对于公共卫生至关重要.

研究的目的:

系统地审查和分析现有的关于甲酸盐暴露对儿童和成人肥胖影响的文献.
为了确定与肥胖相关的特定酸盐.
探索观察到的关联中异质性的潜在来源.

主要方法:

在主要数据库 (PubMed,EMBASE,Scopus,Web of Science) 进行系统的文献搜索,截至2022年7月.
使用修改后的纽卡斯尔-太华尺度 (NOS) 进行包含研究的质量评估.
进行元分析,量化甲酸盐暴露与肥胖之间的关联,根据年龄,性别和地理区域进行子组分析.

主要成果:

儿童暴露于特定的酸盐 (MnBP, MBP, MEP, MiBP, MECPP) 与肥胖有积极的相关性.
成年人接触某些酸盐 (MMP,MEP,MiBP) 与腹部肥胖相关,而其他 (MEHHP,MECPP,MCOP) 与一般肥胖相关.
酸盐暴露与肥胖之间的关联在女性和在欧洲和美国进行的研究中更为显著.

结论:

在儿童和成人中,酸盐暴露与肥胖之间存在显著的关联.
特定的酸盐与儿童和成人肥胖的发展有关.
性和研究地点可能会影响观察到的关联,需要进一步调查.

关键词:

甲基基甲酸二甲基甲酸二甲基甲酸二甲基甲酸二甲基甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸内分泌干扰物干扰内分泌干扰物进行元分析分析.肥胖问题肥胖问题

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