内分泌干扰剂和动脉高血压:一个不断发展的故事
Brasilina Caroccia1, Ilaria Caputo1, Federico Bernardo Rossi1
1Internal Emergency Medicine Unit, Department of Medicine-DIMED University of Padua, Specialized Center for Blood Pressure Disorders-Regione Veneto, 35128 Padua, Italy.
Steroids
|August 7, 2023
概括
像PFAS这样的内分泌干扰化学物质 (EDC) 通过影响基因表达和激素分泌来增加阿尔多斯的产生. 这有助于与环境污染相关的心血管风险.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰化学物质 (EDC) 干扰荷尔蒙通路.
- perfluoroalkyl物质 (PFAS) 的环境污染是一个越来越令人担忧的问题.
- 暴露于PFAS的人群中心血管疾病的高患病率表明与激素干扰有关.
研究的目的:
- 调查PFAS提高阿尔多激素生物合成的潜力.
- 探索PFAS可能影响阿尔多素生产的机制.
- 评估EDCs在心血管健康中的作用.
主要方法:
- 人类上腺皮癌HAC15细胞暴露于PFAS.
- 测量阿尔多氨酸合成酶 (CYP11B2) 的基因表达.
- 评估阿尔多素分泌和反应性氧物种 (ROS) 生产.
- 评估与血管素II (Ang II) 相结合的PFAS影响.
主要成果:
- 在HAC15细胞中,PFAS显著增加了CYP11B2基因表达和阿尔多斯特分泌.
- PFAS促进了线粒体中ROS的产生,影响了阿尔多的生物合成.
- PFAS增强了Ang II对CYP11B2表达和阿尔多素分泌的影响.
- 另一种EDC多化双126 (PCB126) 也增加了CYP11B2的表达和阿尔多素的分泌.
结论:
- PFAS和其他EDC可以增强阿尔多斯特的产生,可能导致高血压和心血管损伤.
- 线粒体ROS的产生与PFAS诱导的阿尔多激素增强有关.
- 鉴于广泛的环境暴露和与心血管疾病的联系,了解EDC对阿尔多素的影响至关重要.
相关概念视频
Hormonal Regulation of Blood Pressure
2.7K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.7K
Antihypertensive Drugs: Angiotensin II Receptor Blockers
780
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
780
Hormonal Regulation
33.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.3K
Hypertension II: Pathophysiology
15
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
15
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
201
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
201
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
690
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
690


