基于性别的研究强调了生物过程,临床疾病和药理干预中的性别差异
Sofia R Bernstein1, Caroline Kelleher1, Raouf A Khalil1
1Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Biochemical pharmacology
|August 7, 2023
概括
研究表明,在多个器官系统中存在显著的性别差异,影响疾病的流行率和严重程度. 承认性别是生物变量对于准确的诊断和男女量身定制的治疗至关重要.
科学领域:
- 生物科学 生物科学
- 医学研究 医学研究
- 身体生理学 身体生理学
背景情况:
- 以前的研究往往忽视了生殖系统以外的生物性别差异.
- 这种忽视导致了误解,错误诊断和临床实践中被忽视的疾病.
- 新出现的证据强调了心血管,脏,内分泌,免疫,神经和肌肉骨系统的基于性别的变化.
研究的目的:
- 突出生物性在健康和疾病中的关键作用.
- 强调需要性别特定的研究和临床方法.
- 在生物医学研究中将性别作为生物变量的整合提供信息.
主要方法:
- 审查当前的科学文献,确定各种器官系统的性别差异.
- 对遗传变异和性腺激素 (雌激素,孕激素,) 对性别特异性健康结果的影响分析.
- 检查与年龄相关的荷尔蒙变化及其对女性疾病表现的影响.
主要成果:
- 在心血管,,内分泌,免疫,神经和肌肉骨系统中发现了显著的性别差异.
- 表明性别之间患有心血管,免疫和神经系统疾病等疾病的发病率和严重程度有所不同.
- 突出女性的性别特异性疾病 (如PCOS,妊娠高血压) 和男性和女性独特的荷尔蒙影响.
结论:
- 性是一个关键的生物变量,它在多个系统中影响健康和疾病.
- 美国国家卫生研究院和其他机构现在要求在研究中考虑性,培养专门的研究中心和出版物.
- 未来的研究和临床实践必须采用性别特定的方法,以改善患者的治疗结果和向治疗.
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