维生素D的新陈代谢不会受到运动活动的影响
Anna Książek1, Aleksandra Zagrodna1, Giovanni Lombardi2
1Department of Biological and Medical Basis of Sport, Faculty of Physical Education and Sports, Wroclaw University of Health and Sport Sciences, 35 Paderewskiego Avenue, 51-612 Wrocław, Poland.
定期的体力活动不会改变维生素D的休息代谢物水平. 免费维生素D (25-OH) DF) 与维生素D代谢物或比率相比,与总量25-OH) DT相比没有更强的相关性.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 运动医学 运动医学
背景情况:
- 较高的体力活动与25-氧维生素D (25-(OH) D水平的升高有关.
- 总25-OH) D (25-OH) DT) 是评估维生素D的标准,但自由25-OH) D (25-OH) DF) 和维生素D代谢物比率 (VMR) 是新兴的生物标志物.
- 定期体育活动对维生素D代谢的影响需要进一步研究.
研究的目的:
- 为了比较25-OH) DF,维生素D代谢物和VMR在不活跃的男性和运动员中.
- 研究定期体育活动对维生素D代谢组的影响.
- 检查25-OH) DT,25-OH) DF,维生素D结合蛋白 (VDBP),维生素D代谢物和VMRs之间的关系.
主要方法:
- 在69名参与者 (27名不活动的男性,18名室内运动员,24名室外运动员) 中,LC-MS/MS分析维生素D代谢物 (25-OH) DT,24,25-OH2D3,3-epi-25-OHD3,1,25-OH2D).
- 根据血清白蛋白和VDBP水平计算25-OH) DF的计算.
- 评估VMR,包括25-OH) D3:24,25-OH) D2和25-OH) D3:3-epi-25-OH) D3的评估.
主要成果:
- 在不活跃的男性和两组运动员之间没有观察到维生素D代谢产物或VMR的显著差异.
- 在25-OH) DT,25-OH) DF和特定代谢物 (24,25-OH) D3,3-epi-25(OH) D3和VMRs (24,25-OH) 2D3之间发现了强烈的相关性:25-OH) D3).
- 在所有参与者群体中,25-OH) DT和25-OH) DF都显示了与多个VMR的反向关联.
结论:
- 定期,长期的体力活动似乎不会影响休息维生素D代谢物度.
- 自由维生素D (25-OH) DF) 与维生素D代谢产物和VMR的相关性并不比总维生素D (25-OH) DT更强.
- 目前使用总水平的维生素D评估方法仍然具有临床相关性.
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