在体外受精后的种族,卵巢反应能力和活产
Iris T Lee1, Dara S Berger1, Nathanael Koelper1
1Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
Fertility and sterility
|August 7, 2023
概括
经过体外受精 (IVF) 的黑人和西班牙裔患者对刺激的卵巢反应更强. 然而,这种增加的反应能力并没有转化为更高的活产率 (LBRs),表明其他因素有助于差异.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 健康差异 在健康上的差异
背景情况:
- 卵巢对淋巴激素刺激的反应是体外受精 (IVF) 成功的一个关键因素.
- 现有的文献表明,在试管婴儿结果中存在种族和民族差异.
- 了解种族/种族是否影响卵巢反应对于解决这些差异至关重要.
研究的目的:
- 在接受试管婴儿的种族/种族群体之间调查卵巢对淋巴激素刺激的反应差异.
- 为了确定卵巢反应是否预测活产率 (LBRs),特别是在非白人患者中.
- 探索可能导致IVF结果种族/民族差异的潜在因素.
主要方法:
- 对接受试管婴儿治疗的白人,亚洲人,黑人和西班牙裔患者进行了回顾性队列研究.
- 用卵巢敏感度指数 (OSI) 测量卵巢响应能力.
- 根据年龄,BMI,不孕症诊断,周期数和其他相关因素进行调整的分析.
主要成果:
- 与白人患者相比,黑人和西班牙裔患者的OSI较高,表明卵巢反应更强.
- 尽管黑人和西班牙裔患者的反应率更高,但与白人患者相比,黑人和西班牙裔患者没有达到统计学上显著的更高的LBR.
- 卵巢敏感度指数是白人和亚洲患者中LBR的适度预测指标,但不是黑人或西班牙裔患者.
结论:
- 在接受试管婴儿的黑人和西班牙裔患者中,较高的卵巢反应率与增加的LBRs无关.
- 除了卵巢刺激反应之外的因素可能导致IVF结果中观察到的种族/民族差异.
- 需要进一步的研究来确定和解决这些差异的根本原因.
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