在免疫检查点抑制剂治疗的设置中胰腺炎和超脂血症
Matthew J Townsend1, Mofei Liu2, Anita Giobbie-Hurder2
1Department of Medicine, Duke University Medical Center, Durham, North Carolina.
免疫检查点抑制剂诱导的胰腺损伤 (ICI-PI) 是罕见的,大多数病例归因于ICI治疗. 早期诊断和监测对于管理ICI-PI和预防胰腺功能不全等并发症至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 可以导致胰腺损伤 (ICI-PI),从无症状的超lipasemia到急性胰腺炎 (AP).
- 由于治疗而产生的ICI-PI的确切比例还不清楚.
- 了解ICI-PI的临床范围和结果对于患者管理至关重要.
研究的目的:
- 在接受ICI的患者中评估超lipasemia的病因.
- 描述ICI-PI的临床特征,管理策略和结果.
- 为了确定ICI诱导的急性胰腺炎 (ICI-AP) 的发病率和风险因素.
主要方法:
- 在2011年至2019年期间接受ICI治疗的6,450名成年癌症患者的回顾性分析.
- 包括364名在ICI开始后血清脂酶升高的患者.
- 评估ICI-PI和ICI-AP的发展,临床特征和治疗结果.
主要成果:
- 在1.6%的患者中,胰腺损伤是由于ICI的使用 (29%的患者患有超脂血症).
- 15%的ICI-AP患者尽管胰腺炎,但无症状.
- ICI-AP与增加对类固醇,液体,住院和永久性ICI停止的需求有关.
结论:
- 在ICI接受者中,少数超lipasemia和胰腺炎病例与治疗有关.
- 腹部成像是有价值的诊断ICI-AP在患者有显著的超lipasemia.
- 建议对ICI-AP患者进行异位胰腺功能衰竭的监测.
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