在第三阶段结肠癌中处方模式的变化
Fang-Shu Ou1, Daniel J Walden2, Joseph J Larson1
1Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota.
在IDEA的合作.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 癌症治疗方法 癌症治疗方法
背景情况:
- 对于切除的第三阶段结肠癌的标准辅助化疗是6个月.
- 在IDEA合作中,研究了3个月的化疗是否与6个月的化疗无差.
- 亚组分析表明,在风险分层方面,非劣势.
研究的目的:
- 评估IDEA合作成果对临床实践的影响.
- 分析2016-2021年辅助化疗方案和持续时间的趋势.
- 评估 IDEA 摘要和手稿出版之前和之后的处方模式.
主要方法:
- 对399名患有第三期结肠癌的患者进行了回顾性分析.
- 对化疗处方实践的评估 (治疗方案和持续时间).
- 在IDEA关键合作出版物之前和之后的治疗模式的比较.
主要成果:
- 在IDEA摘要介绍后 (P<.001) 观察到3个月辅助化疗使用的显著增加.
- 在介绍后,CAPOX (capecitabine/oxaliplatin) 的使用量从14%增加到48% (P<.001).
- 3个月的CAPOX使用随着时间的推移显著增加,无论癌症风险如何 (aOR,1.28;P<.001).
结论:
- 尽管没有达到其主要终点,但IDEA的研究结果影响了处方.
- 临床实践转向更短 (3个月) 的辅助化疗持续时间.
- 在第三阶段结肠癌中,CAPOX成为短期治疗的首选方案.
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