可变翻转角度T1映射和多回声T2和T2*映射的磁共振成像序列允许定量评估犬腰椎退化
Nora Bouhsina1,2, Léa Tur2, Jean-Baptiste Hardel2
1Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, Nantes, France.
概括
新的MRI测绘技术准确量化了狗的椎间盘退化. T1,T2和T2*放松时间显示出强烈的一致性,并随着退化而减少,为跟踪治疗效果提供了潜在的可能性.
科学领域:
- 兽医辐射学 兽医辐射学
- 比较图像成像技术的比较
- 肌肉骨疾病 肌肉骨疾病
背景情况:
- 磁共振成像 (MRI) 是犬间椎间盘 (IVD) 退化诊断的标准.
- 评估IVD退化严重程度和狗的进展的定量方法是有限的.
- 人类研究利用MRI映射序列用于IVD退化量化,但对狗的应用很少.
研究的目的:
- 评估可变翻转角度T1映射和多声波T2和T2*映射用于量化犬腰部IVD退化.
- 评估这些新型狗MRI绘图技术的可行性,可重复性和与已建立的分级系统的相关性.
主要方法:
- 前性方法比较研究,涉及20名临床健康的狗患者.
- 腰部IVD宽度的放射测量和使用T2加权MRI的定性Pfirrmann分级.
- 使用手动的兴趣区域在相应的地图上,量化T1,T2和T2*放松时间在细胞核 (NP) 中.
主要成果:
- 对于NP放松时间测量 (P < 0.01) 的高内和内度协议.
- 放射性IVD宽度,NP放松时间 (T1,T2,T2*) 和Pfirrmann等级 (P<0.01) 之间的负相关性.
- 在Pfirrmann等级I,II和III之间观察到T1,T2和T2*NP放松时间的显著差异 (P<0.01).
结论:
- 在狗患者中,T1,T2和T2*MRI映射序列是可行的和可重复的.
- 测量的NP放松时间随着Pfirrmann等级的增加而减少,这表明退化.
- 这些定量MRI映射方法对评估IVD退化和监测狗的再生治疗有希望.
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