相关实验视频
Updated: Jul 19, 2025
09:49
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
16.0K
治疗性血交换在非免疫性血小板折射性中的作用
Sheharyar Raza1, Christopher J Patriquin1, Karen Yee2
1Division of Hematology, University of Toronto, Canada.
概括
血小板折射性,白血病患者的一个挑战,可以源于联合HLA和HPA合免疫. 血交换为需要输血的严重病例提供了个性化治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 输血医学 输血医学
背景情况:
- 非免疫性血小板折射性带来了重大的临床挑战.
- 结合人体白细胞抗原 (HLA) 和人体血小板抗原 (HPA) 的免疫接种使治疗复杂化.
- 患有危及生命的出血的急性髓性白血病 (AML) 患者特别容易受到伤害.
研究的目的:
- 描述一个复杂的血小板折射性病例.
- 为了确定HLA和HPA合免疫的致病抗体.
- 为了比较非免疫患者的治疗选择.
主要方法:
- 一个患有AML和严重出血的患者的病例报告.
- 对致病性抗体的分析.
- 对治疗方式的审查和比较.
主要成果:
- 这位患者接受了联合的HLA和HPA合免疫接种.
- 考虑并比较了各种不同的治疗方案.
- 血交换成为一种可行的治疗选择.
结论:
- 联合HLA和HPA合免疫是血小板折射性的关键因素.
- 血交换提供了一个可行的,个性化的方法来管理广泛的血小板合免疫.
- 有效的输血策略对于患有危及生命的出血和合免疫的患者至关重要.
相关概念视频
01:22Formation of the Platelet Plug
6.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.7K
02:45Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K