免疫治疗对儿科恶性瘤的影响:APSA癌症委员会的摘要
Lindsay J Talbot1, Timothy B Lautz2, Jennifer H Aldrink3
1St Jude Children's Research Hospital, Memphis, TN, USA.
Journal of pediatric surgery
|August 7, 2023
概括
儿童癌症的生存率有所改善,但免疫疗法为困难病例提供了新的希望. 儿科外科医生必须了解这些新的治疗方法及其外科影响.
科学领域:
- 儿科瘤学 儿科瘤学
- 免疫治疗是一种免疫疗法.
- 手术瘤学手术瘤学
背景情况:
- 儿童癌症仍然是儿童死亡的重要原因,特别是在复发或转移的情况下.
- 传统的治疗方法存在局限性,需要新的治疗方法.
- 免疫疗法已经成为儿童恶性瘤的革命性治疗方式.
研究的目的:
- 审查在儿科瘤学中使用的最常见的免疫疗法.
- 为儿童外科医生讨论这些新型治疗方法的外科相关性.
- 提高对指示,不良事件和手术干预需求的理解.
主要方法:
- 关于儿科免疫治疗的当前文献的综述.
- 专注于嵌合抗原受体 (CAR) T细胞疗法,转基因T细胞受体 (TCR) -T细胞疗法和双特异性T细胞参与剂.
- 讨论FDA批准和临床试验免疫疗法.
主要成果:
- 几个免疫疗法类是FDA批准的或在临床试验中用于儿科癌症.
- 化学抗原受体 (CAR) T细胞疗法,转基因T细胞受体 (TCR) -T细胞疗法和双特异性T细胞参与者是关键例子.
- 这些疗法带来了独特的挑战和潜在的需要进行手术干预.
结论:
- 儿科外科医生必须熟悉免疫疗法课程,指示和不良事件.
- 了解外科手术的影响对于治疗接受免疫治疗的儿童癌症患者的管理至关重要.
- 免疫疗法代表了治疗儿科恶性瘤的范式转变,影响了外科护理.
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