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对过敏性接触性皮肤炎中阳性贴片测试过敏原的分析 患有亚托匹性皮肤炎的患者
Yoon Jin Choi1, Ji Yeon Byun1, You Won Choi1
1Department of Dermatology, Ewha Womans University College of Medicine, Seoul, Korea.
Annals of dermatology
|August 7, 2023
概括
患有亚托皮肤炎 (AD) 的患者接触过敏原敏感化的风险较低. 然而,他们表现出更高的皮质类固醇过敏的风险,如布松胺,突出需要临床意识.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 免疫学 免疫学 免疫学
背景情况:
- 亚托匹性皮肤炎 (AD) 的发病过程涉及Th2歪曲的炎症途径,可能会影响接触敏感性.
- 皮肤屏障功能受损和在阿尔茨海默病中使用局部药物可能会增加敏感化风险.
- 阿尔茨海默病对接触过敏原敏感化频率的净影响仍在争论中.
研究的目的:
- 调查过敏接触性皮肤炎 (ACD) 和有过敏接触性皮肤炎 (AD) 病史的患者接触敏感化的特征.
- 为了比较AD病史和没有AD病史的ACD患者之间的接触敏感率.
主要方法:
- 对2017年3月至2021年3月期间被转诊的515名患者的补丁检测结果的回顾性审查.
- 在AD组 (n=53) 和非AD组 (n=462) 之间的过敏原敏感率的比较.
主要成果:
- 与非AD组 (72.9%) 相比,AD组的任何过敏原阳性率 (56.6%) 显著较低 (p=0.013).
- 在阿尔茨海默症组 (p=0.011),布索尼德敏感性显著更高,而在非阿尔茨海默症组 (p=0.036) 中,秘鲁香更为普遍.
- 硫酸,化和二氧化是两组中最常见的过敏原.
结论:
- 患有亚托邦性皮肤炎的患者表现出接触敏感化的流行率降低.
- 临床医生应考虑在有AD史的ACD患者中增加皮质类固醇过敏的风险.
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