新的Dibenzocyclooctadiene Lignans和Kadsura异构体中的,具有抗炎活性
Le Thi Thuy1, Le Huyen Tram1, Dinh Thi Phuong Anh1
1School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, 100000, Vietnam.
Chemistry & biodiversity
|August 7, 2023
概括
从K. heteroclite中分离出了两种新的二环氧,并测试了它们的抗炎作用. 化合物5显示出瘤亡因子-α (TNF-α) 生产的强烈抑制.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- K. heteroclite 是一种生物活性化合物的植物来源.
- 瘤坏死因子-α (TNF-α) 在炎症反应中起着关键作用.
- 调节TNF-α的产生是炎症性疾病的治疗点.
研究的目的:
- 从K. heteroclite.中分离和描述新的化合物.
- 评估这些化合物在调节TNF-α生产中的潜力.
主要方法:
- 使用多种染色学技术进行化学研究.
- 通过光谱方法阐明结构 (HR-ESI-MS,1D/2D NMR,ECD).
- 在体外评估TNF-α抑制在脂聚糖 (LPS) 刺激的RAW264.7细胞.
主要成果:
- 分离了两种新的二环氧八二烯 (1和2) 和14种已知的化合物.
- 化合物5表现出TNF-α产生最强烈的抑制 (IC50 = 6.16±0.14μM).
- 化合物1,3和6显示出显著的抑制,而化合物2,4,9,10,13,15和16显示出中度的抑制.
结论:
- 克.异构素是具有抗炎作用潜力的双环氧的宝贵来源.
- 化合物5是作为抗炎剂进一步研究的有希望的候选物.
- 这项研究有助于了解K. heteroclite的化学成分及其生物活动.
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