在多腔体血管化人类心脏器官中电代谢合
Mohammad Ghosheh1,2, Avner Ehrlich1,2,3, Konstantinos Ioannidis1,2,3
1Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Nature biomedical engineering
|August 7, 2023
概括
研究人员开发了人类心脏器官,以研究心脏生理学. 这些有机体揭示了线粒体呼吸和电活动之间的新联系,这对于理解心律和心律失常至关重要.
科学领域:
- 心血管生物学 心血管生物学
- 生物医学工程 生物医学工程
- 有机物技术 有机物技术
背景情况:
- 人类和小动物模型呈现生理差异,限制了心脏生理学研究.
- 开发特定的人类模型对于准确研究心脏功能和疾病至关重要.
研究的目的:
- 为研究心脏生理学和心律失常创建功能性人类心脏器官.
- 为了研究线粒体呼吸和心肌细胞电活动之间的关系.
主要方法:
- 在异性压力下生成多腔体,血管化的人类心脏器官.
- 使用嵌入式传感器 (>10 Hz) 同时测量氧气吸收,细胞外场潜力和心脏收缩.
- 分析电-线粒体合及其在心律中的作用.
主要成果:
- 心脏器官系统表现出1Hz的心脏呼吸周期与电气,而不是机械活动相结合.
- 线粒体振荡被确定为这些呼吸周期的驱动因素.
- 电-线粒体合的抑制导致心律失常行为,化疗性线粒体通过这种途径诱导心律失常.
结论:
- 一种新的电-线粒体合机制调节了人类心脏器官的心脏节奏.
- 这种微生理系统为研究心律中的线粒体动力学提供了一个平台.
- 这些发现有助于进一步了解人类心脏生理学和心律失常机制.
相关概念视频
01:27Specialized Characteristics of Cardiac Muscles
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
01:16Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...