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环境空气污染,遗传风险和英国生物银行中的端粒长度
Linxi Tang1,2, Dankang Li1,2, Jianing Wang1,2
1Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, 430030, Wuhan, China.
Journal of exposure science & environmental epidemiology
|August 7, 2023
概括
空气污染与端粒长度 (TL) 变化有非线性联系. 遗传易感性可能与空气污染物相互作用,影响基因组衰老并识别有风险的个体.
科学领域:
- 环境健康科学 环境健康科学
- 基因组学就是基因组学.
- 衰老研究研究 衰老研究
背景情况:
- 端粒长度 (TL) 作为基因组衰老的生物标志物.
- 之前关于空气污染和TL协会的研究产生了不一致的结果.
- 遗传敏感性在改变空气污染与TL关系中的作用尚未被探索.
研究的目的:
- 研究暴露于环境空气污染和端粒长度之间的关联.
- 检查遗传敏感性是否会改变空气污染和端粒长度之间的关系.
主要方法:
- 利用了来自433,535名英国生物库参与者的数据.
- 使用土地利用回归模型估计每年对NO2,NOx,PM10和PM2.5的平均暴露.
- 从与端粒相关的SNP构建基因风险评分 (GRS),并通过qPCR测量白细胞TL;使用多变量线性回归分析关联.
主要成果:
- 在空气污染物和TL之间观察到非线性 (NO2/NOx的U形,PM10/PM2.5的L形) 相关性.
- NO2,NOx和PM2.5的下四分位数与TL相反相关,而NO2的最高四分位数显示出正相关性.
- 在暴露于高四分位空气污染物 (NO2,NOx,PM2.5) 和遗传风险之间发现了协同作用.
结论:
- 这项研究揭示了空气污染与端粒长度之间的新型非线性关联.
- 遗传因素与空气污染相互作用,影响端粒长度和基因组衰老.
- 这些发现为识别易受影响的人群和理解空气污染对健康影响的基因环境相互作用提供了洞察力.
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