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基于脂质纳米粒子的mRNA输送系统用于癌症免疫疗法

Jieun Han1,2, Jaesung Lim3,4, Chi-Pin James Wang3,4

  • 1Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seobu-ro 2066, Suwon, Gyeonggi, 16419, Republic of Korea.

Nano convergence
|August 7, 2023
PubMed
概括

脂质纳米颗粒 (LNP) 对于传递信使RNA (mRNA) 癌症免疫疗法至关重要. 本综述总结了LNP增强mRNA在癌症治疗中的进展,挑战和未来方向.

关键词:
癌症免疫疗法癌症免疫疗法脂质纳米粒子 (LNP) 是一种传递者RNA (mRNA) 是一种传递器RNA.与瘤相关的抗原 (TAA)

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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