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Updated: Jul 19, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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在单细胞数据中,用对比方法分离出有趣的突出变异

Ethan Weinberger1, Chris Lin1, Su-In Lee2

  • 1Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA.

Nature methods
|August 7, 2023
PubMed
概括

这项研究引入了对比变异推理 (contrastiveVI),这是单细胞RNA测序 (scRNA-seq) 数据的新计算框架. ContrastiveVI有效地分离了共享和治疗特定的细胞变异,改善了对治疗反应的分析.

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