在患有发育性阅读障碍和并发性注意力缺陷/多动性障碍的儿童中,白质通道扩散性的特性
Ryan J Slaby1,2,3, C Nikki Arrington4,5,6, Jeffrey Malins1,2
1Department of Psychology, Georgia State University, 140 Decatur St SE, Atlanta, GA, 30303, USA.
Journal of neurodevelopmental disorders
|August 7, 2023
概括
高长度 (SLF) 中的白质完整性在患有发育性阅读障碍 (DD) 和/或注意力缺陷/多动症障碍 (ADHD) 的儿童之间存在差异. 研究结果表明,白质的扩散性随着DDD+ADHD组合到典型发育的连续性而增加.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 放射学 放射学是一门学科.
背景情况:
- 发育性阅读障碍 (DD) 和注意力缺陷/多动障碍 (ADHD) 是常见的神经发育障碍,脑网络存在重叠缺陷.
- 之前的研究表明,在患有DD或ADHD的个体中,白质通道异常存在.
- 患有共病性DD和ADHD (DD+ADHD) 个体的白质微观结构仍未得到充分研究.
研究的目的:
- 为了研究DD,ADHD和DD+ADHD并发症儿童的白质扩散差异.
- 在这些群体中探索白质微观结构与阅读和注意力的行为测量之间的关系.
主要方法:
- 参与者包括被诊断患有DD (n=40),DD+ADHD (n=22) 或典型发育 (TD) (n=20) 的三年级和四年级学生.
- 白质的扩散性通过微分异型 (FA) 和通过扩散张力成像 (DTI) 的平均扩散性 (MD) 来评估.
- 所有参与者都进行了阅读和注意力的行为评估.
主要成果:
- 在DD+ADHD和TD组中,在左侧和右侧上长纵筋 (SLF) -Parietal和SLF-Temporal终点内,平均FA的显著差异.
- 对于这些SLF通道,DD组的平均FA值是中间的,位于DD+ADHD和TD组之间.
- 没有观察到平均扩散度 (MD) 或大脑行为关系的显著差异.
结论:
- 在SLF中,特别是FA中的白质完整性,似乎在DD和ADHD诊断的连续性上有所变化.
- 这些发现表明SLF中白质变化的梯度,在共患DD+ADHD组中差异最为明显.
- 这些结果有助于理解这些高度共发性神经发育障碍的神经生物学基础.
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