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在ADAMTS14 (rs4747096) 和骨关节炎中单个核酸多态之间的相关性调查:元分析

Baojie Li¹, Xiaojing Li¹, Linjing Zhang¹

¹Department of Orthopedics, The People's Hospital of Weifang, 151 Guangwen Street, Kuiwen District, Weifang, 261000, Shandong, China.

Journal of orthopaedic surgery and research

|August 7, 2023

概括

ADAMTS14 rs4747096单核酸多态性 (SNP) 与骨关节炎 (OA) 的风险增加有关. 这一元分析证实了多种遗传模型中这种SNP和OA易受性之间的显著关联.

科学领域:

遗传学遗传学是一个
类风湿病学类风湿病学
分子生物学分子生物学

背景情况:

将ADAMTS14 rs4747096单核酸多态 (SNP) 与骨关节炎 (OA) 联系在一起的证据仍然存在争议.
本研究通过调查这种特定的SNP和OA风险之间的关联来解决相互矛盾的数据.

研究的目的:

为了确定ADAMTS14 rs4747096多态性和发展骨关节炎的风险之间的关系.
提供关于这种遗传关联的现有研究的结论性元分析.

主要方法:

在四个数据库中进行了系统的电子搜索,以寻找rs4747096多态和OA的研究.
分析评估了使用R.软件的等位基因,添加基因,衰退基因和主导基因模型中的关联.
为了评估效应大小,计算了几率比率 (OR) 和95%置信区间 (CI).

主要成果:

包含707例OA病例和859例对照的四项研究被纳入了元分析.
在等位基,添加基和主导基模型中发现了OA风险和rs4747096多态的显著相关性.
衰退模型没有显示出显著的关联,但其他模型表明OA风险增加 (例如,Allele OR: 1.48 [1.26-1.73]).

结论:

ADAMTS14 rs4747096的多态性显著与对骨关节炎的敏感性增加有关.
这一发现有助于了解影响OA发展的遗传因素.

关键词:

亚当斯14年亚当斯14年进行元分析分析.骨关节炎是一种骨关节炎.单个核酸的多态性.易感性易感性易感性需要的钱是什么? rs4747096

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