孕激素原始卵巢刺激 (PPOS) 协议在接受试管婴儿治疗的老年患者中产生较低的euploidy率
Angel Hsin-Yu Pai1, Yen Ju Sung1, Chia-Jung Li1
1Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, 5 Fu-Shin Street, Kweishan, Taoyuan, Taiwan.
Reproductive biology and endocrinology : RB&E
|August 7, 2023
概括
与GnRH对抗剂协议相比,孕激素主导的卵巢刺激 (PPOS) 协议可能会降低老年试管婴儿患者的euploidy率. 需要进一步的研究来证实这些发现,并确定针对PPOS的最佳患者选择.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 遗传学 是一个遗传学.
背景情况:
- 孕激素主导的卵巢刺激 (PPOS) 协议是用于体外受精 (IVF) 的常规性腺激素释放激素 (GnRH) 反对者协议的替代方案.
- 在PPOS协议中外源性孕激素对在植入前遗传测试 (PGT-A) 周期中对euploidy率的潜在影响尚未完全理解.
研究的目的:
- 为了比较使用PPOS协议与常规GnRH抗剂协议进行PGT-A周期的患者的euploidy率.
- 调查PPOS协议是否会影响接受PGT-A的患者的euploidy率.
主要方法:
- 从2018年1月到2021年12月,对128个PGT-A周期进行了回顾性队列研究.
- 对27-45岁的不孕妇女进行分析,她们接受了PPOS或GnRH抗剂协议与IVF/ICSI.
- 在两组之间比较了胚胎囊形成和euploidy率,并根据年龄 (≥38岁和<38岁) 进行了亚组分析.
主要成果:
- 与GnRH抗组相比,PPOS组的患者表现出明显较低的囊胚细胞形成和euploidy率.
- 在老年子组 (≥38岁) 中,PPOS与明显较低的囊胚形成率 (45.8%与59.9%) 和euploidy率 (5.4%与26.7%) 相关.
- 在较年轻的子组 (<38岁) 中没有观察到这些比率的显著差异. 二次结果在各组之间是可比的.
结论:
- 与GnRH抗剂协议相比,PPOS协议可能会降低老年试管婴儿患者的euploidy率.
- 由于研究的追溯性质,应谨慎解释结果.
- 需要进一步的大规模研究来确认疗效并确定PPOS协议的最佳患者选择.
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