接受全关节或膝关节置换的脆弱患者的预康复:联合PREP可行性随机对照试验的协议
Tanzeela Khalid1, Yoav Ben-Shlomo1,2, Wendy Bertram1,3
1Bristol Medical School, University of Bristol, Bristol, UK.
Pilot and feasibility studies
|August 7, 2023
概括
这项可行性研究探讨了接受关节置换手术的脆弱患者的预康复. 手术前的运动和蛋白质补充可能会改善恢复,为更大规模的试验铺平道路.
科学领域:
- 老年医学 老年医学
- 整形外科手术 整形外科手术
- 康复科学 康复科学 康复科学
背景情况:
- 在英格兰,50岁以上的成年人中,脆弱性约占8%.
- 虚弱与关节置换手术后的较差结果有关.
- 手术前的干预措施,如运动和蛋白质补充,显示出改善患者康复的潜力.
研究的目的:
- 评估随机对照试验 (RCT) 在接受关节或膝关节置换的脆弱患者预康复的可行性.
- 探索未来的大规模RCT的最佳试验设计和交付.
- 收集关于招募,坚持和接受预康复计划的数据.
主要方法:
- 一个多中心的可行性研究,两臂,实用性RCT (联合PREP研究).
- 招募了60名计划进行关节或膝关节置换的脆弱个体 (≥65岁).
- 干预组每天接受蛋白质补充剂和12周的家庭炼计划;对照组接受了通常的护理.
- 在基线和12周通过问卷收集的数据,与嵌入的定性研究.
主要成果:
- 该研究将为未来的第三阶段RCT提供关键的可行性数据.
- 关键可行性结果包括资格和招聘率,干预坚持以及试验/干预可接受性.
- 定性数据将探索患者的经验和参与或退出原因.
结论:
- 这项可行性研究对于设计一个强大的RCT来评估脆弱关节置换患者的预康复是必不可少的.
- 结果将为未来的第三阶段RCT提供信息,以确定手术前运动和蛋白质补充剂在康复过程中的有效性.
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