下垂体神经内分泌瘤:它是良性的还是恶性的?
1Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. chleens@paik.ac.kr.
Brain tumor research and treatment
|August 7, 2023
概括
2022年世界卫生组织分类改进了使用转录因子的垂体神经内分泌瘤 (PitNET) 亚型化. 关于将PitNETs分类为良性或恶性,大多数表现出良性行为,争论仍在继续.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 世界卫生组织 (WHO) 在2022年更新了下垂体瘤分类.
- 这一修订包括垂体神经内分泌瘤 (PitNETs) 的详细组织学亚型.
- 针对特定的脑垂体转录因子的免疫组织化学对于这种分类至关重要.
研究的目的:
- 讨论2022年世卫组织对垂体神经内分泌瘤 (PitNETs) 的分类的影响.
- 为解决有关PitNETs分配的行为代码的持续辩论.
- 突出瘤亚型化中的垂体转录因子的诊断作用.
主要方法:
- 审查2022年世卫组织对垂体瘤的分类标准.
- 对 pituitary转录因子 (PIT1,TPIT,SF1,GATA3,ERα) 的免疫组织化学分析.
- 讨论PitNETs的临床行为和复发率.
主要成果:
- 新的分类强调基于细胞谱系和转录因子概况的组织学亚型.
- 关于将PitNETs分类为良性 (代码0) 和恶性 (代码3) 存在重大争论.
- 大多数PitNET表现为良性行为,在手术后复发率不到5%,攻击性行为不到1%.
结论:
- 2022年世卫组织分类为诊断PitNETs提供了一个精细的框架.
- 皮特网的临床行为主要是良性的,尽管有一些侵入性倾向.
- 使用免疫组织化学的准确亚型化对于理解PitNET行为和指导治疗至关重要.
更多相关视频
07:43Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
18.9K
09:33Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
1.2K
相关概念视频
Cancer
48.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.7K
The Pituitary Gland
6.9K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
6.9K
Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Hormones of the Pituitary Gland
6.7K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.7K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
