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前列腺的增殖性炎症性缩中的俱乐部状细胞

Franklin W Huang^1,2,3, Hanbing Song^1,2, Hannah Nw Weinstein^1,2

¹Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.

The Journal of pathology

|August 7, 2023

概括

在炎症组织中发现的和与癌症相关的前列腺俱乐部样细胞可能在肺俱乐部细胞再生和前列腺癌的发展中发挥作用. 这些细胞对抗雄激素治疗敏感.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
细胞生物学细胞生物学
在瘤学瘤学.

背景情况:

俱乐部细胞是肺上皮细胞,对于肺部的保护和再生至关重要.
之前的研究已经在人类前列腺和尿道中发现了类似于球状细胞的细胞.
这些前列腺俱乐部状细胞的空间定位和功能仍然不清楚.

研究的目的:

在正常和癌症前列腺组织中识别和空间定位俱乐部细胞.
为了研究俱乐部状细胞与炎症和前列腺癌的关联.
探索前列腺俱乐部样细胞的潜在作用和治疗敏感性.

主要方法:

对于五种俱乐部细胞标记物 (CP,LTF,MMP7,PIGR,SCGB1A1) 的染色体RNA在位杂交.
对无病的器官供体前列腺和急性前列腺切除术样本的分析.
前列腺上皮细胞有机体培养和基因表达分析.

主要成果:

前列腺外围区域的俱乐部细胞基因表达与炎症和在增殖性炎症性缩 (PIA) 中的中间细胞有关.
俱乐部样细胞在前列腺切除标本中更为丰富,并且与高度前列腺癌和TMPRSS2:ERG (ERG+) 基因融合有关.
含有俱乐部状细胞的前列腺器官在抗雄激素治疗后显示出较低的雄激素信号.

结论:

在PIA中存在一群类似俱乐部细胞,可能类似于肺俱乐部细胞.
炎症可能导致前列腺谱系的可塑性,而这些俱乐部细胞可能容易发生瘤转化.
前列腺俱乐部样细胞对抗雄激素疗法敏感,表明潜在的治疗点.

关键词:

在TMPRSS2:ERGSS2:ERGSS2中使用.缩性缩 (英语:Atrophy atrophy) 是一种损伤.俱乐部细胞细胞俱乐部细胞这是一种炎症炎症炎症炎症.中间细胞的中间细胞.血统的可塑性血统的可塑性这是一种有机物质的有机物质.前列腺癌是前列腺癌.

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