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斯特里克尼精液与大脑科伊兹 (Atractylodes Macrocephala Koidz) 结合,通过调节亡来减轻类风湿性关节炎的作用

Xiaoxin Wang¹, Yuling Li¹, Huihui Lou¹

¹College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Ji'nan, 250355, Shandong, Peoples R China.

Current computer-aided drug design

|August 8, 2023

概括

斯特里克尼精液与Atractylodes Macrocephala Koidz (SA) 结合,显示出抗风湿性关节炎 (RA) 的作用. 它在辅助性关节炎 (AA) 鼠中的治疗机制涉及调节亡信号通路,为RA提供潜在的治疗方法.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
传统中国医药传统中国医药

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节疼痛和残疾.
斯特里奇尼精液与Atractylodes Macrocephala Koidz (SA) 结合显示了对RA的治疗作用,没有毒性.
对于SA治疗RA的精确药理机制尚不清楚.

研究的目的:

阐明SA在治疗RA中的药理机制.
确定与RA相关的SA的活性成分,目标和途径.
通过体内实验验验证网络药理学预测.

主要方法:

网络药理学被用来选SA的活性成分,预测标,并确定途径.
进行了基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 分析.
建立了一个辅助性关节炎 (AA) 鼠标模型,用于预测机制的体内验证.

主要成果:

网络药理学确定了81个活性成分和141个SA的目标,其中ALB,IL-6,TNF和IL-1β是RA的核心目标.
GO和KEGG分析表明SA与TNF信号通路在RA治疗中的关联.
在体内实验证实了SA在改善AA老鼠症状,调节免疫反应和调节亡相关蛋白质 (例如Fas,Bax,Caspase 3,Bcl-2) 的有效性.

结论:

酸盐表现出显著的抗RA效应.
在AA大鼠中SA的治疗机制与亡信号通路的调节有关.
SA提出了一种对RA治疗有前途的治疗策略.

关键词:

斯特里赫尼的精子是什么意思灭症 (apoptosis) 是一种死亡的过程.吸引类巨头科伊兹 (Atractylodes macrocephala koidz) 是一个巨头类动物.网络药理学.药理学机制药理学机制类风湿性关节炎类风湿性关节炎

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