在接受ozanimod治疗的复发性多发性硬化症患者中,SARS-CoV-2疫苗接种和感染
Bruce A C Cree1, Rachel Maddux2, Amit Bar-Or3
1Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Annals of clinical and translational neurology
|August 8, 2023
概括
接受Ozanimod治疗的复发性多发性硬化症患者对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗接种和感染表现出强烈的血清学反应. 在接种疫苗的人群中,COVID-19不良事件并不严重.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 病毒学 病毒学
背景情况:
- 奥萨尼莫德是一种口服的基1-酸盐受体调节剂,用于复发性多发性硬化症 (RMS).
- 了解用ozanimod治疗RMS患者对SARS-CoV-2疫苗接种和感染的免疫反应对于患者管理至关重要.
- 在DAYBREAK研究中,评估了接受ozanimod的RMS患者的结果.
研究的目的:
- 调查ozanimod治疗RMS参与者的SARS-CoV-2疫苗接种和感染的血清反应.
- 为了确定血清学反应的预测因素.
- 评估疫苗接种和感染后的临床结果,包括不良事件.
主要方法:
- 这项研究包括来自DAYBREAK延伸研究 (NCT02576717) 的288名RMS参与者.
- 参与者接受了mRNA或非mRNA的SARS-CoV-2疫苗,没有接种疫苗,或有COVID-19相关的不良事件.
- 评估了尖端受体结合域 (RBD) 抗体水平和SARS-CoV-2感染的血清学证据.
主要成果:
- 在完全接种疫苗的参与者中 (n=148),90%的人在没有先前接触SARS-CoV-2的情况下实现了尖端RBD抗体血清转化.
- mRNA疫苗接种预测了更高的抗体水平;绝对淋巴细胞计数,年龄,BMI和性别没有.
- 接种疫苗的参与者中COVID-19相关的不良事件不严重,不严重,完全康复.
结论:
- 大多数接受ozanimod治疗的RMS患者对SARS-CoV-2疫苗接种和感染产生了强大的血清反应.
- 响应独立于参与者的特征或绝对淋巴细胞计数.
- 在这个队列中,在接种疫苗后没有观察到与COVID-19相关的严重不良事件.
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