来自机会性病原体Basidiobolus meristosporus的周期性
Cheng Zhao1, Jiaojiao Qu1, Fan Peng1
1Engineering Research Center of Fungal Biotechnology, Ministry of Education; Research Center on Entomogenous Fungi, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
Journal of natural products
|August 8, 2023
概括
从一种真菌病原体中分离出了三种新型循环,meristosporins A-C. 两种化合物表现出细胞毒性,这表明它们在真菌引起的人类细胞损伤中的作用.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 机会主义的真菌病原体会导致人体细胞受伤.
- 了解真菌代谢物对于识别毒性因素至关重要.
研究的目的:
- 从真菌病原体中分离和描述新型循环.
- 研究这些化合物的生物合成途径和生物活性.
主要方法:
- 使用NMR,MS/MS和Marfey分析进行隔离和结构阐明.
- 通过非核糖体合成酶基因集群进行生物合成途径分析.
- 在RAW264.7和293T细胞上进行细胞毒性测定.
主要成果:
- 鉴定出了三种新的循环,即美里斯托斯波林A,B和C.
- 梅里斯托斯氨酸A具有一个不寻常的氨基酸特征.
- 化合物1和2对测试的细胞系表现出细胞毒性.
结论:
- 已识别的循环是来自真菌病原体的新型二次代谢产物.
- 梅里斯托斯波林A和B具有细胞毒性.
- 这些化合物可能会导致人类细胞的真菌诱导损伤.
相关概念视频
Fungal Phylum Basidiomycota
125
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
125
Bacterial Phylum Planctomycetes
34
Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
34
Fungal Group Zygomycota
43
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
43
Bacterial Phylum Actinobacteria
36
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
36
Bacterial Phylum Spirochaetes
40
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
40
Bacterial Phylum Tenericutes
42
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
42


