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通过免疫细胞死亡增强"吃我信号",以增强癌症免疫治疗的潜力

Yong Xi^1,2, Lijie Chen^3,4, Jian Tang²

¹Department of Thoracic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.

Immunological reviews

|August 8, 2023

概括

免疫细胞死亡 (ICD) 通过释放激活抗瘤免疫力的信号来增强癌症免疫疗法. 基于纳米技术的药物输送系统正在出现,以扩大ICD以获得更有效的癌症治疗.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

免疫性细胞死亡 (ICD) 是启动抗瘤免疫反应的关键机制.
有效的癌症免疫疗法依赖于在ICD级联过程中放大"吃我信号".
放射治疗,光动力疗法 (PDT) 和光热疗法 (PTT) 等各种疗法可以诱导或增强ICD.

研究的目的:

审查免疫细胞死亡 (ICD) 的新兴诱导剂.
探索基于纳米结构的药物递送系统,以加强ICD.
讨论ICD诱导剂与纳米输送系统和免疫治疗剂的组合,以获得协同作用的抗瘤作用.

主要方法:

关于ICD诱导器和纳米输送系统的当前文献的审查.
分析治疗策略,包括化学放射治疗,PDT和PTT用于ICD诱导.
检查纳米载体在提供针对性ICD和强化免疫治疗的药物的作用.

主要成果:

基于纳米结构的药物递送系统提供精确和定时的药物释放,以有效地诱导ICD,降低毒性.
将纳米输送系统与ICD诱导剂和免疫治疗剂相结合,可以导致协同的抗瘤免疫反应.
新兴的ICD诱导剂和纳米技术方法显示出对推进癌症免疫治疗的重大前景.

结论:

基于纳米技术的药物输送系统对于优化癌症免疫治疗的ICD诱导至关重要.
通过先进的纳米输送策略利用ICD为癌症治疗提供了一个有希望的途径.
跨学科的合作对于将基于ICD诱导的免疫疗法转化为临床实践至关重要.

关键词:

药物输送系统是药物输送系统.免疫微观环境免疫微环境免疫性细胞死亡免疫性细胞死亡免疫疗法免疫疗法纳米医药是一种纳米医药.协同治疗是一种协同治疗.

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