复杂双胞胎怀孕的神经发育结果:前性观察性研究
1Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, UK.
概括
双胞胎妊娠中出现复杂单胆双眼 (MCDA) 双胞胎怀孕的儿童表现出更高的不良神经发育结果. 在这些高风险双胞胎怀孕中,早期监测对于及时干预和最佳管理至关重要.
科学领域:
- 围产儿医学 围产儿医学
- 神经发育儿科 神经发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 双胞胎怀孕,特别是单胞胎双胞胎 (MCDA) 类型,面临患产周并发症的风险增加.
- 复杂双胞胎怀孕幸存者的长期神经发育结果尚未完全理解.
- 不良的神经发育结果可以显著影响孩子的长期健康和生活质量.
研究的目的:
- 在复杂的MCDA双胞胎怀孕中,确定1岁后神经发育不良结果的发生率.
- 为了比较复杂的MCDA双胞胎和不复杂的双胞胎怀孕之间的神经发育结果.
- 确定双胞胎怀孕幸存者中不良神经发育的独立预测因子.
主要方法:
- 一项前性队列研究,涉及327名来自双胞胎怀孕的儿童,评估年龄在12至60个月之间.
- 利用年龄和阶段问卷®版本3 (ASQ-3) 来评估神经发育领域.
- 采用混合效应多变量逻辑回归来分析复杂的MCDA双胞胎怀孕和异常的ASQ-3分数之间的关联.
主要成果:
- 复杂的MCDA双胞胎怀孕的孩子与不复杂的双胞胎相比,异常ASQ-3分数的几率几乎是双倍 (14.5%vs7.6%).
- 在患有复杂的MCDA怀孕的儿童中,观察到明显更高的粗体运动障碍率 (8.5%与2.9%相比).
- 经过产前干预的复杂的MCDA怀孕显示出异常ASQ-3得分的比率要高得多 (28.1%对1.7%).
结论:
- 复杂的MCDA双胞胎怀孕独立地与不良神经发育结果的更高风险有关,无论早产.
- 长期的神经发育跟踪对于早期识别和治疗受影响儿童至关重要.
- 研究结果强调了复杂双胞胎怀孕幸存者的专业护理和监测的重要性.
关键词:
在ASQQ中,我们可以使用ASQQ.年龄和阶段问卷问卷身体残疾就是残疾.对于胎儿的干预.这是一个单一的monochorionic.神经发育的结果.选择性的胎儿生长限制.双胞胎怀孕 双胞胎怀孕 双胞胎怀孕双胞胎 - 双胞胎输血综合征更多相关视频
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