强大的交叉队列肠道微生物组与COVID-19严重程度的联系
Junhui Li1,2, Tarini Shankar Ghosh1,2, Rachel McCann3
1School of Microbiology, University College Cork, Cork, Ireland.
Gut microbes
|August 8, 2023
概括
这项研究揭示了强大的肠道微生物组生物标志物,用于COVID-19的严重程度. 微生物组的变化预测疾病的进展和死亡率,建议针对性的饮食干预措施,以更好地管理.
科学领域:
- 微生物组研究的研究.
- 传染病流行病学 传染病流行病学
- 基因组分析 基因组分析
背景情况:
- 之前的研究探索了肠道微生物组与单一队列中COVID-19严重程度的联系.
- 报告的微生物组生物标志物在不同国际患者群体中的稳定性仍然不清楚.
研究的目的:
- 为了确定可靠的肠道微生物组生物标志物来确定COVID-19疾病严重程度.
- 建立临床预后和死亡率的预测模型.
- 为COVID-19管理提出针对微生物群的饮食策略.
主要方法:
- 八个中枪元基因组和23个16S rRNA基因扩增序列队伍的元分析.
- 分析了来自COVID-19患者和对照组的3400多个便样本.
- 利用关系式饮食-微生物群数据库来预测饮食模式.
主要成果:
- 疾病严重程度与显著的分类学和功能性肠道微生物群差异相关.
- 微生物组的变化在诊断后7-30天达到顶峰,然后随着时间的推移正常化.
- 确定了预测严重程度的核心物种; Actinomyces oris 丰度与死亡率相关.
- 严重程度与古老,真菌,病毒和寄生虫社区之间的相关性.
结论:
- 确定了强大的,交叉队列的COVID-19微生物组生物标志物.
- 开发了用于临床预后测试的准确预测模型.
- 拟议的生物标志物向饮食调节肠道微生物群用于COVID-19管理.
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