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Updated: Jul 19, 2025

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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作为抗莱什曼病剂的提亚胺衍生物:合成,生物评估,结构活性关系,ADMET,分子对接和分子动力学模拟研究

Tamanna1, Chaoping Fu2, Meshil Qadir1

  • 1Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.

Journal of biomolecular structure & dynamics
|August 8, 2023
PubMed
概括

研究人员合成了新型thiadiazine-2-thione化合物,并发现它们对Leishmania major.表现出显著的leishmanicidal活性. 最强效的化合物显示为未来治疗莱什曼病的候选药物具有前途.

关键词:
在AMDET中,AMDET就是AMDET.莱什曼尼亚大型 (Leishmania major) 是一个很大的病.蒂亚迪亚二烯 (Thiadiazine thione) 是一种氨酸.莱什曼尼cidal活动活动.分子对接的分子对接.分子动态模拟分子动态模拟

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