青的使用和上皮卵巢癌的风险:一个全国性的嵌套病例控制研究
Guoqiao Zheng1, Mette Tuxen Faber1, Louise Baandrup1
1Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
概括
定期使用青与患上上皮质卵巢癌 (EOC) 的风险较低有关. 保护作用随着剂量增加而增加,这表明这种常见的止痛药的剂量反应关系.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 卵巢上皮癌 (EOC) 是一个重要的全球健康问题.
- 常见的止痛药,如片对癌症风险的潜在影响需要调查.
- 了解与EOC风险相关的可修改因素对于预防策略至关重要.
研究的目的:
- 为了确定是否类醇消费与患上上皮质卵巢癌的风险降低有关.
- 探索帕拉塞他使用和EOC发病率之间的潜在剂量反应关系.
- 分析EOC的不同组织学亚型之间的关联.
主要方法:
- 通过使用丹麦人口数据进行了一项全国性嵌套病例控制研究.
- 9,589个EOC病例与2000年至2019年的383,549个对照进行了匹配.
- 对的使用是根据处方数据定义的,并根据近期,持续时间,累积剂量和强度进行分类;采用了条件后勤回归.
主要成果:
- 总体而言,青的使用 ("曾经"使用) 与降低EOC风险 (OR 0.92,95% CI 0.87-0.97) 有统计学显著的关联.
- 风险降低在最近的用户中更为明显,并且显示出剂量-反应模式.
- 高累积剂量和高强度的降醇使用与13%和14%的风险降低有关;这种效果在血清细胞和透明细胞EOC亚型中最显著.
结论:
- 降醇使用与上皮卵巢癌的风险降低有关,呈现出剂量反应关系.
- 这些发现表明,青对EOC有潜在的保护作用.
- 建议进行进一步的研究来证实这些发现,并阐明潜在的生物机制.
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