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双重协同瘤特异性聚合物纳米粒子,用于有效的化疗免疫疗法

Jiajia Xiang^1,2, Kexin Liu¹, Hongxia Xu¹

¹Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 8, 2023

概括

这项研究引入了结合诺坎塔里丁和的新型纳米粒子,以克服癌症.

科学领域:

在瘤学瘤学.
纳米医学是一种纳米医学.
癌症免疫学癌症免疫学

背景情况:

癌症治疗面临的挑战来自细胞周期检查点和PD-L1上调.
现有的化疗免疫疗法受到瘤自卫机制的限制.

研究的目的:

设计用于协同化学免疫治疗的诺卡利丁-代码传递纳米粒子 (NC-NP).
克服癌症的抵抗机制,包括细胞循环停止和PD-L1表达.

主要方法:

开发了对瘤酸度敏感的纳米颗粒,用于控制释放1,2-氨酸环- (DACHPt) 和诺卡丁 (NCTD).
研究了NCTD在抑制蛋白酸酶2A (PP2A) 和降低PD-L1.1的作用.
在实验室和4T1瘤模型中评估NC-NP的疗效.

主要成果:

在酸性瘤微环境中,NC-NP证明了DACHPT和NCTD的瘤特异释放.
NCTD有效地缓解了细胞循环停止和减少PD-L1表达,增强了化疗.
NC-NP促进了T细胞的招募和强大的抗瘤免疫反应,导致显著的瘤回归.

结论:

NC-NP提供了一种双重协同的方法,结合化疗和免疫疗法.
这种策略有效地克服了癌细胞的防御机制,并提高了治疗结果.
NC-NP代表了先进癌症治疗的一个有前途的范式.

关键词:

癌症药物输送癌症药物输送化疗免疫疗法化疗免疫疗法组合疗法治疗组合治疗.免疫性细胞死亡免疫性细胞死亡有协同效应的效应.

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